Raganata, Alvitto Bagas (2025) Targeting breast cancer angiogenesis pathway using myricetin from local grape seed through in-silico approach / Alvitto Bagas Raganata</p>. Diploma thesis, Universitas Negeri Malang.
Full text not available from this repository.Abstract
p Breast cancer remains one of the leading causes of death worldwide with incidence rates continuously increasing. One crucial mechanism in its progression is angiogenesis which can be targeted through the Wnt5a signaling pathway. This study aims to explore the potential of Myricetin a bioactive compound from red grape seeds as an angiogenesis inhibitor in breast cancer through an in-silico approach. The methods employed include molecular docking HOMO-LUMO analysis and evaluation based on Lipinski rsquo s Rule of Five using various software tools such as AutoDock Open Babel and Biovia Discovery Studio. The results showed that Myricetin violated only one Lipinski criterion and exhibited a stronger binding affinity to beta -catenin (-5.07 kcal/mol) compared to the control drug Doxorubicin. Furthermore Myricetin demonstrated a higher dipole moment suggesting better interaction in polar environments. Amino acid residue analysis indicated that Myricetin and Doxorubicin interacted at similar binding sites on target proteins. This study highlights Myricetin rsquo s potential as a candidate angiogenesis inhibitor targeting the Wnt5a pathway in breast cancer. /p
| Item Type: | Thesis (Diploma) |
|---|---|
| Divisions: | Fakultas Matematika dan IPA (FMIPA) > Departemen Biologi (BIO) > S1 Biologi |
| Depositing User: | library UM |
| Date Deposited: | 07 Jul 2025 04:29 |
| Last Modified: | 09 Sep 2025 03:00 |
| URI: | http://repository.um.ac.id/id/eprint/395763 |
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